Backed by Science
Metavo’s ability to manage blood sugar, boost metabolism, and improve health is no small feat.* Our scientists have spent the better part of a decade researching and discovering a new bioactive ingredient found only in a unique subset of avocados – Avocatin-B (AvoB™).
Backed by Preclinical Studies
Dr. Spagnuolo’s university-led clinical trial quantifies the impact of AvoB™ in human subjects.
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How Metavo regulates blood sugar
After we eat, the amount of glucose in our blood rises
Insulin is released to bring blood sugar levels back down to "normal" levels
When the body starts to ignore the insulin message (insulin resistance), blood sugar levels rise and can lead to weight gain, hypertension, prediabetes and type 2 diabetes.
Metavo works to support normal blood sugar levels and maintain healthy metabolism.
If you are interested in learning more about the technical science behind Metavo, check out our clinical studies and published research.
SP Nutraceuticals report on Metavo
This report illuminates the science behind the powerful bioactive compound AvoB, harnessed from a unique subset of avocados, and chromium, an essential mineral that improves insulin action in the body. This report looks at chronic conditions like diabetes and metabolic syndrome and how the health benefits of avocados, AvoB, and chromium work together to restore insulin sensitivity and blood glucose levels.READ THE FULL REPORT
A clinical trial published in Molecular Nutrition & Food Research, 2019
In this 8-week trial, mice were fed high-fat diets and given AvoB, which led to improved glucose tolerance, glucose utilization, and insulin sensitivity. Afterward, a randomized, double-blind, placebo-controlled clinical trial in healthy human participants confirmed the findings and AvoB’s nutritional and clinical importance.READ THE FULL REPORT
A study published in Scientific Reports, 2020
This study establishes the promising pharmacokinetic and biodistribution of AvoB in biological systems. Pharmacokinetics is the study of the bodily absorption, distribution, metabolism, and excretions of drugs and substances of interest. Biodistribution is a tracking method where compounds of interest travel in a human or animal subject.READ THE FULL REPORT
A clinical trial published in Clinical Obesity, 2019
This trial looked at the role of chromium as a weight loss agent and established that chromium supplementation was associated with some improvements in body composition in subjects with obesity. However, the clinical relevance of chromium as a weight loss aid remains uncertain.READ THE FULL REPORT
A clinical trial published in the Journal of Clinical Pharmacy and Therapeutics, 2014
This trial established in randomized controlled trials that chromium mono- and combined supplementation significantly improved glycaemic control. The evidence suggests favourable effects of chromium supplementation on glycaemic control in patients with diabetes.READ THE FULL REPORT
Our founder, Dr. Paul Spagnuolo speaks with Allison Tannis, on the Natural Health Influencer Podcast.
The Natural Health Influencer podcast is hosted by nutrition expert and author Allison Tannis of @deliciouslygeeky. She speaks with Dr. Spagnuolo who gives a detailed breakdown of what insulin resistance is and how it affects our health before explaining the research that he has been doing on avocados for the past 10 years.LISTEN TO THE PODCAST