Avocado-derived polyols for use as novel co-surfactants in low energy self-emulsifying microemulsions

Avocado (Persea americana Mill.; Lauraceae) seed-derived polyhydroxylated fatty alcohols (PFAs) or polyols (i.e., avocadene and avocadyne) are metabolic modulators that selectively induce apoptosis of leukemia stem cells and reverse pathologies associated with diet-induced obesity.A pilot pharmacokinetic evaluation of an AvoB™ formulation in C57BL/6J mice revealed appreciable accumulation in whole blood and biodistribution in key target tissues. Lastly, incorporation of AvoB™ in SEDDS significantly improved encapsulation of the poorly water-soluble drugs naproxen and curcumin.
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